Buy Cyproheptadine HCl (Periactin) 4 mg tablets

Buy Cyproheptadine HCl (Periactin) tablets online

How and where to order Periactin (Cyproheptadine Hydrochloride) 4 mg tablets online:

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Type:	Cyproheptadine brand, Periactin generic
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Indications and usage:

Perennial and seasonal allergic rhinitis

Vasomotor rhinitis

Allergic conjunctivitis due to inhalant allergens and foods

Mild, uncomplicated allergic skin manifestations of urticaria and angioedema

Amelioration of allergic reactions to blood or plasma

Cold urticaria

Dermatographism

In migraine and vascular types of headache

As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.

Dosage and administration:

Dosage of Periactin (Cyproheptadine) 4 mg tablets should be individualized according to the needs and the response of the patient.

Pediatric patients

Age 2 to 6 years. The total daily dosage for pediatric patients may be calculated on the basis of body weight or body area using approximately 0.25 mg/kg/day or 8 mg per 2square meter of body surface (8 mg/m2). The usual dose is 2 mg (1/2 tablet) two or three times a day, adjusted as necessary to the size and response of the patient. The dose is not to exceed 12 mg a day.

Age 7 to 14 years. The usual dose is 4 mg (1 tablet) two or three times a day adjusted as necessary to the size and response of the patient. The dose is not to exceed 16 mg a day.

Adults

The total daily dose for adults should not exceed 0.5 mg/kg/day. The therapeutic range is 4 to 20 mg a day, with the majority of patients requiring 12 to 16 mg a day. An occasional patient may require as much as 32 mg a day for adequate relief. It is suggested that dosage be initiated with 4 mg (1 tablet) three times a day and adjusted according to the size and response of the patient.

Dosage forms and strengths:

Periactin (Cyproheptadine Hydrochloride) 4 mg oral tablets.

Overdosage:

Cyproheptadine and other antihistamines overdosage reactions may vary from central nervous system depression to stimulation especially in pediatric patients. Also, atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing, etc.) as well as gastrointestinal symptoms may occur.

If vomiting has not occurred spontaneously, the patient should be induced to vomit with syrup of ipecac.

If patient is unable to vomit, perform gastric lavage followed by activated charcoal. Isotonic or 1/2 isotonic saline is the lavage of choice. Precautions against aspiration must be taken especially in infants and children.

When life threatening CNS signs and symptoms are present, intravenous physostigmine salicylate may be considered. Dosage and frequency of administration are dependent on age, clinical response, and recurrence after response.

Saline cathartics, as milk of magnesia, by osmosis draw water into the bowel and, therefore, are valuable for their action in rapid dilution of bowel content.

Stimulants should not be used.

Vasopressors may be used to treat hypotension.

The oral LD50 of cyproheptadine is 123 mg/kg, and 295 mg/kg in the mouse and rat, respectively.

Contraindications:

Cyproheptadine (Periactin) should not be used for therapy of an acute asthmatic attack.

Newborn or premature infants

This drug should not be used in newborn or premature infants. Use in infants has been associated with apnea, cyanosis, and respiratory difficulty.

Nursing mothers

Because of the higher risk of antihistamines for infants generally, and for newborn and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

Other conditions:

Hypersensitivity to cyproheptadine and other drugs of similar chemical structure

Monoamine oxidase inhibitor therapy

Angle-closure glaucoma

Stenosing peptic ulcer

Symptomatic prostatic hypertrophy

Bladder neck obstruction

Pyloroduodenal obstruction

Elderly, debilitated patients

Warnings:

Pediatric patients

Overdosage of cyproheptadine and other antihistamines, particularly in infants and young children, may produce hallucinations, central nervous system depression, convulsions, respiratory and cardiac arrest, and death.

Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation.

CNS depressants

Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.

Activities requiring mental alertness

Patients taken cyproheptadine should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery. Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients.

Precautions:

Periactin (Cyproheptadine Hydrochloride) has an atropine-like action and, therefore, should be used with caution in patients with:

History of bronchial asthma

Increased intraocular pressure

Hyperthyroidism

Cardiovascular disease

Hypertension

Information for patients:

Antihistamines, including cyproheptadine may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.

Drug interactions:

MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.

Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.

Related medications:

Albuterol (Salbutamol)

Side effects, adverse reactions:

The side effects of cyproheptadine that appear frequently are drowsiness and somnolence. Many patients who complain initially of drowsiness may no longer do so after the first three or four days of continuous administration.

Adverse reactions which have been reported with the use of antihistamines:

Central nervous system: sedation, sleepiness (often transient), dizziness, disturbed co-ordination, confusion, restlessness, excitation, nervousness, tremor, irritability, aggressive behaviour, insomnia, paraesthesias, neuritis, convulsions, euphoria, hallucinations, hysteria, faintness

Integumentary: allergic manifestation of rash and oedema, excessive perspiration, urticaria, photosensitivity

Special senses: acute labyrinthitis, blurred vision, diplopia, vertigo, tinnitus

Cardiovascular: hypotension, palpitation, tachycardia, extrasystoles, anaphylactic shock

Haematological: haemolytic anaemia, leucopoenia, agranulocytosis, thrombocytopoenia

Digestive system: cholestasis, hepatic failure, hepatitis, hepatic function abnormality, dryness of mouth, epigastric distress, anorexia, nausea, vomiting, diarrhoea, constipation, jaundice

Genitourinary: frequency of micturition, difficult micturition, urinary retention, early menses

Respiratory: dryness of nose and throat, thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness, epistaxis

Miscellaneous: fatigue, chills, headache, increased appetite/weight gain

Use in specific populations:

Nursing mothers

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from cyproheptadine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric use

Safety and effectiveness in pediatric patients below the age of two have not been established.

Geriatric use

Clinical studies of Periactin (Cyproheptadine HCl) tablets 4 mg did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Use in pregnancy:

Reproduction studies have been performed in rabbits, mice, and rats at oral or subcutaneous doses up to 32 times the maximum recommended human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to cyproheptadine. Cyproheptadine has been shown to be fetotoxic in rats when given by intraperitoneal injection in doses four times the maximum recommended human oral dose. Two studies in pregnant women, however, have not shown that cyproheptadine increases the risk of abnormalities when administered during the first, second and third trimesters of pregnancy. No teratogenic effects were observed in any of the newborns. Nevertheless, because the studies in humans cannot rule out the possibility of harm, cyproheptadine should be used during pregnancy only if clearly needed.

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Here is a list of popular medications containing cyproheptadine as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

Trade name of the drug	Pharmaceutical forms and doses	Companies
Cipla-Actin	Tablets; Oral; Cyproheptadine Hydrochloride 4 mg	Cipla
Periactin	Syrup; Oral; Cyproheptadine Hydrochloride 2 mg / 5 ml Tablets; Oral; Cyproheptadine Hydrochloride 4 mg	Merck Avantgarde B L Hua Johnson & Johnson M & H Manufacturing Sigma-Tau Pharmaceuticals
Peritol	Drops; Oral; Cyproheptadine Hydrochloride 1.5 mg / ml Liquid; Oral; Cyproheptadine Hydrochloride 1.5 mg / ml Syrup; Oral; Cyproheptadine Hydrochloride 2 mg / 5 ml Tablets; Oral; Cyproheptadine Hydrochloride 4 mg	Egis Medphano Arzneimittel Themis Medicare

Resource Links

Reliability and Validity for Life Care Planners - Why are we, as clinical practitioners, interested in research aimed at validating the process of life care planning?

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Introduction to Evidence-based Practice - The practice of evidence-based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research.

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Sources of Research Information - There are numerous resources available to life care planners, but professionas need to know where information exists . . .