Cyproheptadine Online



Cyproheptadine (trade names include Periactin, Cipla-Actin, Ciplactin, Peritol, Practin, Pronicy, Viternum) is a first-generation antihistamine medication from antihistamines for systemic use pharmacological group. This medicine is prescribed for the therapy of hay fever, allergic rhinitis, other allergic reactions; as a preventive treatment against migraine, cluster headaches. It is also used off-label in the treatment of Cushing's syndrome, cyclical vomiting syndrome in infants, to improve akathisia in people on antipsychotic medications, to treat various dermatological conditions, including pruritus, urticaria, psychogenic itch, drug-induced hyperhidrosis (excessive sweating); prevention of blister formation for some people with epidermolysis bullosa simplex; to increase appetite and weight gain in people with anorexia, anorexia nervosa, cystic fibrosis, in children who are wasting or with failure to thrive; in the management of moderate to severe cases of serotonin syndrome, SSRI induced sexual dysfunction.
Cyproheptadine is also indicated in veterinary for cats as an appetite stimulant and as an adjunct in the treatment of asthma; as a second line treatment for pituitary pars intermedia dysfunction in horses.
It works as very potent antihistamine or inverse agonist of the H1 receptor.

How and where to order Periactin (Cyproheptadine) 4 mg tablets online on FLCPR:

Shop:DFH PHARMACY
Stores:PHARMA DOCTOR
Prices:from $0.39 per pill
Discount:10% coupon: DFHDCC
Forms:Cyproheptadine Hydrochloride 4 mg tablets
Quantity:30-360 pills
Type:Cyproheptadine brand, Periactin generic
Payment:Visa, MasterCard, AmEx, eCheck (ACH), Bitcoin
Delivery:Standard airmail and trackable courier services
Shipping:Worldwide, including USA, UK, Europe, Canada, Australia


Periactin (Cyproheptadine) tablets 4 mg

Related medications:

  • Azelastine (Astelin)
  • Cetirizine (Zyrtec)
  • Desloratadine (Clarinex)
  • Dexamethasone (Dexone)
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  • Fexofenadine (Allegra)
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  • Mometasone (Elocon)
  • Montelukast (Singulair)
  • Olopatadine (Patanol)
  • Promethazine (Phenergan)
  • Triamcinolone (Aristocort)


    Pharmacological and medical categories:

  • Anti allergic drugs
  • Anticholinergic medications
  • Antihistamine pills
  • Appetite stimulants
  • First-generation antihistamines
  • H1-antihistaminics
  • Histamine H1-receptor antagonists
  • Local anesthetics
  • Serotonin receptor antagonists
  • Veterinary medications, pet meds
  • Weight gain pills


    ATC codes:

  • R - Respiratory system
  • R06 - Antihistamines for systemic use
  • R06A - Antihistamines for systemic use
  • R06AX - Other antihistamines for systemic use
  • R06AX02 - Cyproheptadine


    ICD-10 codes:

  • Cushing's syndrome - E24
  • Cystic fibrosis - E84
  • Eating disorders - F50
  • Anorexia nervosa, unspecified - F50.00
  • Other extrapyramidal and movement disorders - G25
  • Drug induced akathisia - G25.71
  • Migraine - G43
  • Other headache syndromes - G44
  • Vasomotor and allergic rhinitis - J30
  • Allergic rhinitis due to pollen - J30.1
  • Pruritus - L29
  • Pruritus scroti - L29.1
  • Eccrine sweat disorders - L74
  • Primary focal hyperhidrosis, axilla - L74.510
  • Other disorders of the skin and subcutaneous tissue - L80-L99
  • Male erectile dysfunction - N52
  • Drug-induced erectile dysfunction - N52.2
  • Epidermolysis bullosa - Q81
  • Epidermolysis bullosa simplex - Q81.0
  • Nausea and vomiting - R11
  • Lack of expected normal physiological development in childhood and adults - R62
  • Adult failure to thrive - R62.7
  • Symptoms and signs concerning food and fluid intake - R63
  • Anorexia - R63.0
  • Superficial injury of knee and lower leg - S80
  • Blister (nonthermal), right lower leg, initial encounter - S80.821A
  • Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified - T43


    Indications and usage:

  • Perennial and seasonal allergic rhinitis
  • Vasomotor rhinitis
  • Allergic conjunctivitis due to inhalant allergens and foods
  • Mild, uncomplicated allergic skin manifestations of urticaria and angioedema
  • Amelioration of allergic reactions to blood or plasma
  • Cold urticaria
  • Dermatographism
  • In migraine and vascular types of headache
  • As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.


    Dosage and administration:

    Dosage of Periactin (Cyproheptadine) 4 mg tablets should be individualized according to the needs and the response of the patient.

    Pediatric patients

    Age 2 to 6 years. The total daily dosage for pediatric patients may be calculated on the basis of body weight or body area using approximately 0.25 mg/kg/day or 8 mg per 2square meter of body surface (8 mg/m2). The usual dose is 2 mg (1/2 tablet) two or three times a day, adjusted as necessary to the size and response of the patient. The dose is not to exceed 12 mg a day.

    Age 7 to 14 years. The usual dose is 4 mg (1 tablet) two or three times a day adjusted as necessary to the size and response of the patient. The dose is not to exceed 16 mg a day.

    Adults

    The total daily dose for adults should not exceed 0.5 mg/kg/day. The therapeutic range is 4 to 20 mg a day, with the majority of patients requiring 12 to 16 mg a day. An occasional patient may require as much as 32 mg a day for adequate relief. It is suggested that dosage be initiated with 4 mg (1 tablet) three times a day and adjusted according to the size and response of the patient.


    Dosage forms and strengths:

    Periactin (Cyproheptadine Hydrochloride) 4 mg oral tablets.


    Overdosage:

    Cyproheptadine and other antihistamines overdosage reactions may vary from central nervous system depression to stimulation especially in pediatric patients. Also, atropine-like signs and symptoms (dry mouth; fixed, dilated pupils; flushing, etc.) as well as gastrointestinal symptoms may occur.

    If vomiting has not occurred spontaneously, the patient should be induced to vomit with syrup of ipecac.

    If patient is unable to vomit, perform gastric lavage followed by activated charcoal. Isotonic or 1/2 isotonic saline is the lavage of choice. Precautions against aspiration must be taken especially in infants and children.

    When life threatening CNS signs and symptoms are present, intravenous physostigmine salicylate may be considered. Dosage and frequency of administration are dependent on age, clinical response, and recurrence after response.

    Saline cathartics, as milk of magnesia, by osmosis draw water into the bowel and, therefore, are valuable for their action in rapid dilution of bowel content.

    Stimulants should not be used.

    Vasopressors may be used to treat hypotension.

    The oral LD50 of cyproheptadine is 123 mg/kg, and 295 mg/kg in the mouse and rat, respectively.


    Contraindications:

    Cyproheptadine (Periactin) should not be used for therapy of an acute asthmatic attack.

    Newborn or premature infants

    This drug should not be used in newborn or premature infants. Use in infants has been associated with apnea, cyanosis, and respiratory difficulty.

    Nursing mothers

    Because of the higher risk of antihistamines for infants generally, and for newborn and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.

    Other conditions:

  • Hypersensitivity to cyproheptadine and other drugs of similar chemical structure
  • Monoamine oxidase inhibitor therapy
  • Angle-closure glaucoma
  • Stenosing peptic ulcer
  • Symptomatic prostatic hypertrophy
  • Bladder neck obstruction
  • Pyloroduodenal obstruction
  • Elderly, debilitated patients


    Warnings:

    Pediatric patients

    Overdosage of cyproheptadine and other antihistamines, particularly in infants and young children, may produce hallucinations, central nervous system depression, convulsions, respiratory and cardiac arrest, and death.

    Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation.

    CNS depressants

    Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.

    Activities requiring mental alertness

    Patients taken cyproheptadine should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery. Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients.


    Precautions:

    Periactin (Cyproheptadine Hydrochloride) has an atropine-like action and, therefore, should be used with caution in patients with:

  • History of bronchial asthma
  • Increased intraocular pressure
  • Hyperthyroidism
  • Cardiovascular disease
  • Hypertension


    Information for patients:

    Antihistamines, including cyproheptadine may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.


    Drug interactions:

    MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines.

    Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents.


    Side effects, adverse reactions:

    The side effects of cyproheptadine that appear frequently are drowsiness and somnolence. Many patients who complain initially of drowsiness may no longer do so after the first three or four days of continuous administration.

    Adverse reactions which have been reported with the use of antihistamines:

  • Central nervous system: sedation, sleepiness (often transient), dizziness, disturbed co-ordination, confusion, restlessness, excitation, nervousness, tremor, irritability, aggressive behaviour, insomnia, paraesthesias, neuritis, convulsions, euphoria, hallucinations, hysteria, faintness
  • Integumentary: allergic manifestation of rash and oedema, excessive perspiration, urticaria, photosensitivity
  • Special senses: acute labyrinthitis, blurred vision, diplopia, vertigo, tinnitus
  • Cardiovascular: hypotension, palpitation, tachycardia, extrasystoles, anaphylactic shock
  • Haematological: haemolytic anaemia, leucopoenia, agranulocytosis, thrombocytopoenia
  • Digestive system: cholestasis, hepatic failure, hepatitis, hepatic function abnormality, dryness of mouth, epigastric distress, anorexia, nausea, vomiting, diarrhoea, constipation, jaundice
  • Genitourinary: frequency of micturition, difficult micturition, urinary retention, early menses
  • Respiratory: dryness of nose and throat, thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness, epistaxis
  • Miscellaneous: fatigue, chills, headache, increased appetite/weight gain


    Use in specific populations:

    Nursing mothers

    It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from cyproheptadine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

    Pediatric use

    Safety and effectiveness in pediatric patients below the age of two have not been established.

    Geriatric use

    Clinical studies of Periactin (Cyproheptadine HCl) tablets 4 mg did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.


    Use in pregnancy:

    Reproduction studies have been performed in rabbits, mice, and rats at oral or subcutaneous doses up to 32 times the maximum recommended human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to cyproheptadine. Cyproheptadine has been shown to be fetotoxic in rats when given by intraperitoneal injection in doses four times the maximum recommended human oral dose. Two studies in pregnant women, however, have not shown that cyproheptadine increases the risk of abnormalities when administered during the first, second and third trimesters of pregnancy. No teratogenic effects were observed in any of the newborns. Nevertheless, because the studies in humans cannot rule out the possibility of harm, cyproheptadine should be used during pregnancy only if clearly needed.


    Pregnancy categories:

  • A - Australia
  • B - United States (No evidence of risk in humans)


    Salts and other forms:

  • Cyproheptadine Base
  • Cyproheptadine Acefyllinate
  • Cyproheptadine Anhydrous
  • Cyproheptadine Epoxide
  • Cyproheptadine Glucuronide
  • Cyproheptadine Hydrochloride
  • Cyproheptadine Hydrochloride Anhydrous
  • Cyproheptadine Hydrochloride Hydrate
  • Cyproheptadine Hydrochloride Monohydrate
  • Cyproheptadine Hydrochloride Sesquihydrate
  • Cyproheptadine N-Oxide
  • Cyproheptadine Pyridoxal Phosphate
  • Cyproheptadine Orotate


    Synonyms, international and chemical names:

  • 4-(5H-dibenzo[a-e]cycloheptatrienylidene)-1-metylpiperidine
  • Chlorhydrate de Cyproheptadine
  • Cipro-Heptadina
  • Ciproeptadina
  • Ciproheptadin
  • Ciproheptadina
  • Cyproheptadin
  • Cyproheptadine HCl
  • Cyproheptadinhydrochlorid
  • Cyproheptadini Hydrochloridum
  • Cyproheptadinum
  • Cyproheptadyna


    Brands, generics, trade names:

  • Cipla-Actin - Cipla
  • Ciplactin - Cipla, LBS Laboratory
  • Periactin - Merck, Avantgarde, B L Hua, Johnson & Johnson, M & H Manufacturing, Sigma-Tau Pharmaceuticals
  • Periactine - Merck, Teofarma
  • Peritol - Egis, Medphano Arzneimittel, Themis Medicare
  • PMS-Cyproheptadine - Pharmascience
  • Practin - Wockhardt
  • Pronicy - Kalbe Farma
  • Viternum - Labomed Instituto Farmaceutico, Juste Quimico-Farmaceutica, OM Pharma, Senosiain Laboratorios


    APIs used in medicine in combinations with cyproheptadine::

  • Amino Acids
  • Arginine
  • Carnitine
  • Clonixin
  • Deanol Aceglumate
  • Dexamethasone
  • Ergotamine Tartrate
  • Fosforylethanolamine
  • Ginkgo Biloba
  • Hematoporphyrin
  • Lysine
  • Metoclopramide
  • Minerals
  • Pantethine
  • Pepsin
  • Peptone
  • Pyritinol
  • Sorbitol
  • Tricholine Citrate
  • Vitamins


    Here is a list of popular medications containing cyproheptadine as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Cipla-Actin
  • Tablets; Oral; Cyproheptadine Hydrochloride 4 mg
  • Cipla
  • Periactin
  • Syrup; Oral; Cyproheptadine Hydrochloride 2 mg / 5 ml
  • Tablets; Oral; Cyproheptadine Hydrochloride 4 mg
  • Merck
  • Avantgarde
  • B L Hua
  • Johnson & Johnson
  • M & H Manufacturing
  • Sigma-Tau Pharmaceuticals
  • Peritol
  • Drops; Oral; Cyproheptadine Hydrochloride 1.5 mg / ml
  • Liquid; Oral; Cyproheptadine Hydrochloride 1.5 mg / ml
  • Syrup; Oral; Cyproheptadine Hydrochloride 2 mg / 5 ml
  • Tablets; Oral; Cyproheptadine Hydrochloride 4 mg
  • Egis
  • Medphano Arzneimittel
  • Themis Medicare



  • References:

  • Cyproheptadine main article on Wikipedia: https://en.wikipedia.org/wiki/Cyproheptadine
  • Cyproheptadine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/cyproheptadine
  • Cyproheptadine Hydrochloride compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyproheptadine-hydrochloride
  • Cyproheptadine on DrugBank: https://go.drugbank.com/drugs/DB00434
  • Cyproheptadine Hydrochloride on DrugBank: https://go.drugbank.com/salts/DBSALT000625
  • Cyproheptadine FAQ on MedlinePlus (revised 02/15/2018): https://medlineplus.gov/druginfo/meds/a682541.html
  • Cyproheptadine Hydrochloride tablets drug label info on DailyMed (revised May 21, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Cyproheptadine containing drugs on Drugs-About.com: https://drugs-about.com/ing/cyproheptadine.html
  • Cyproheptadine for sale on Pharma Doctor: https://pharma-doctor.com/cyproheptadine.html
  • Cyproheptadine international drug names on Drugs.com: https://www.drugs.com/international/cyproheptadine.html
  • Teva Cyproheptadine Hydrochloride tablets USP 4 mg for oral use official prescribing information from the U.S. FDA: https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Periactin (Cyproheptadine Hydrochloride) 4 mg tablets product information from GP2U TeleHealth (revised 17 November 2011): https://gp2u.com.au/static/pdf/P/PERIACTIN-PI.pdf
  • Periactin (Cyproheptadine Hydrochloride Sesquihydrate) 4 mg tablets consumer medicine information from NPS MedicineWise (revised November 2020): https://www.nps.org.au/medicine-finder/periactin-tablets
  • Periactin (Cyproheptadine Hydrochloride) 4 mg tablets package information leaflet from Medicines.org.au (revised October 2007): https://apps.medicines.org.au/files/mkcperia.pdf

    Revised: February 2021



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