Selegiline Online

How and where to order Deprenyl, Eldepryl (Selegiline) 5 mg tablets or capsules online on FLCPR website:

Prices:from $0.54 per pill
Discount:10% coupon: DFHDCC
Forms:Selegiline Hydrochloride 5 mg capsules or tablets
Quantity:30-360 pills
Type:Selegiline brand, Deprenyl brand, Eldepryl generic
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Delivery:Standard airmail and trackable courier services
Shipping:Worldwide, including USA, UK, Europe, Canada, Australia

Selegiline or L-Deprenyl (trade names include Eldepryl, Emsam, Deprenyl, Anipryl, Egibren, Jumex, Jumexil, Moverdin, Selegos, Selgian, Selgin, Zelapar) is an antiparkinsonian drug from monoamine oxidase type B (MAO-B) inhibitors pharmacological group. This medication is used to treat symptoms of Parkinson's disease, parkinsonism, shaking palsy, paralysis agitans, such as dementia in Alzheimer's disease, shakiness (tremor), muscle stiffness, loss of normal movement, sudden switching between normal movement and stiffness, other movement disorders. This is a cognitive enhancing smart anti aging drug that improves brain functions, cognitive actions, concentration, the range of motion and ability to walk, dress, exercise. Selegiline works by increasing and extending the effects of levodopa, and helping to slow the progress of Parkinson's disease. Deprenyl is usually used in combination with other antiparkinson medications (e.g., levodopa, carbidopa).
Emsam (Selegiline in the form of transdermal patch) is prescribed for the therapy of depression and major depressive disorder.
This medication is also indicated to treat the symptoms of Cushing's disease and cognitive dysfunction in veterinary medicine for dogs, pets and animals.
Selegiline was tested and studied for the treatment of attention deficit hyperactivity disorder (ADHD); to stop smoking tobacco or cannabis.

Eldepryl, Emsam, Deprenyl (Selegiline Hydrochloride) logo

Related medications:

  • Amantadine (Symmetrel)
  • Apomorphine (Taluvian)
  • Bromocriptine (Parlodel)
  • Budipine (Parkinsan)
  • Cabergoline (Dostinex)
  • Carbidopa, Entacapone, Levodopa (Stalevo)
  • Carbidopa, Levodopa (Sinemet)
  • Dihydroergocryptine Mesylate (Almirid)
  • Donepezil (Aricept)
  • Entacapone (Comtan)
  • Galantamine (Reminyl)
  • Levodopa (Larodopa)
  • Memantine (Namenda)
  • Pergolide (Permax)
  • Piracetam (Nootropil)
  • Piribedil (Trivastal)
  • Pramipexole (Mirapex)
  • Procyclidine (Kemadrin)
  • Rasagiline (Azilect)
  • Rivastigmine (Exelon)
  • Ropinirole (Requip)
  • Rotigotine (Neupro)
  • Tolcapone (Tasmar)
  • Trihexyphenidyl (Artane)

    Pharmacological and medical categories:

  • Anti aging drugs
  • Antidepressants
  • Antiparkinson medicines
  • Pharmaceutical drugs for the treatment of Parkinson's disease
  • Central nervous system agents
  • Dopaminergic antiparkinsonism agents
  • Meds to treat ADHD
  • Monoamine oxidase B (MAO-B) inhibitors
  • Stop smoking pills
  • Substituted phenethylamines
  • Veterinary medications, pet meds

    ATC codes:

  • N - Nervous system
  • N04 - Anti-parkinson drugs
  • N04B - Dopaminergic agents
  • N04BD - Monoamine oxidase B inhibitors
  • N04BD01 - Selegiline

    ICD-10 codes:

  • Cushing's syndrome - E24
  • Dementia in Alzheimer's disease ( G30.-+ ) - F00*
  • Cannabis related disorders - F12
  • Major depressive disorder, single episode - F32
  • Major depressive disorder, recurrent - F33
  • Attention-deficit hyperactivity disorders - F90
  • Parkinson's disease - G20
  • Other specified degenerative diseases of nervous system - G31.8
  • Mild cognitive impairment, so stated - G31.84
  • Tobacco abuse counseling - Z71.6

    Indications and usage:

    Eldepryl (Selegiline Hydrochloride) capsules or tablets is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.

    Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of "off" time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state).

    Dosage and administration:

    Selegiline is administered as monotherapy in the early phase of the disease, or as adjunctive therapy with levodopa (with / without a peripheral decarboxylase inhibitor). In each case the initial dose is 5 mg taken at breakfast and lunch. There is no evidence that additional benefit will be obtained from the administration of higher doses.

    After two to three days of adjunctive therapy, an attempt may be made to reduce the dose of levodopa (10-30%) if levodopa-related adverse reactions occur. Further reductions of levodopa may be possible during continued selegiline therapy.

    Double-blind studies on early-phase parkinsonian patients showed that patients receiving selegiline monotherapy manage significantly longer without levodopa therapy than controls receiving placebo. These patients could also maintain their ability to work longer.

    After the initiation of levodopa therapy, selegiline potentiates and extends the effect of levodopa, and thus a reduction of levodopa dosage is possible. By adding selegiline to levodopa therapy the fluctuations in disability, e.g.end-of-dose type fluctuations, can be reduced.

    Dosage forms and strengths:

    Eldepryl (Selegiline Hydrochloride) 5 mg and 10 mg capsules or tablets for oral use.


    No cases of overdosage by selegiline pills are known. However, experience gained during selegiline's development reveal that some individuals exposed to doses of 600 mg/day selegiline suffered severe hypotension and psychomotor agitation.

    Theoretically, overdosage causes significant inhibition of both MAO-A and MAO-B and thus, symptoms may resemble those observed with non-selective MAOIs, particularly disorders of the central nervous and cardiovascular systems (e.g. drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucination, hypertension, hypotension, vascular collapse, rapid and irregular pulse, precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis). There is no specific antidote and the treatment is symptomatic.


    Selegiline is contraindicated in patients with a known hypersensitivity to this drug. This medication is also is contraindicated for use with meperidine. This contraindication is often extended to other opioids.


    Selegiline should not be used at daily doses exceeding those recommended (10 mg/day) because of the risks associated with non-selective inhibition of MAO.

    The selectivity of selegiline for MAO-B may not be absolute even at the recommended daily dose of 10 mg a day. Rare cases of hypertensive reactions associated with ingestion of tyramine-containing foods have been reported in patients taking the recommended daily dose of selegiline. The selectivity is further diminished with increasing daily doses. The precise dose at which selegiline becomes a non-selective inhibitor of all MAO is unknown, but may be in the range of 30 to 40 mg a day.

    Severe CNS toxicity associated with hyperpyrexia and death have been reported with the combination of tricyclic antidepressants and non-selective MAOIs (Nardil, Parnate). A similar reaction has been reported for a patient on amitriptyline and Eldepryl. Another patient receiving protriptyline and selegiline pills developed tremors, agitation, and restlessness followed by unresponsiveness and death two weeks after Eldepryl was added. Related adverse events including hypertension, syncope, asystole, diaphoresis, seizures, changes in behavioral and mental status, and muscular rigidity have also been reported in some patients receiving Eldepryl and various tricyclic antidepressants.

    Serious, sometimes fatal, reactions with signs and symptoms that may include hyperthermia, rigidity, myoclonus, autonomic instability with rapid fluctuations of the vital signs, and mental status changes that include extreme agitation progressing to delirium and coma have been reported with patients receiving a combination of fluoxetine hydrochloride (Prozac) and non-selective MAOIs. Similar signs have been reported in some patients on the combination of Selegiline (10 mg a day) and selective serotonin re-uptake inhibitors including fluoxetine, sertraline and paroxetine.

    Since the mechanisms of these reactions are not fully understood, it seems prudent, in general, to avoid this combination of Eldepryl and tricyclic antidepressants as well as Selegiline HCl and selective serotonin re-uptake inhibitors. At least 14 days should elapse between discontinuation of Eldepryl and initiation of treatment with a tricyclic antidepressant or selective serotonin re-uptake inhibitors. Because of the long half-lives of fluoxetine and its active metabolite, at least five weeks (perhaps longer, especially if fluoxetine has been prescribed chronically and/or at higher doses) should elapse between discontinuation of fluoxetine and initiation of treatment with selegiline tablets or capsules.



    Some patients given selegiline may experience an exacerbation of levodopa associated side effects, presumably due to the increased amounts of dopamine reaction with super sensitive, post-synaptic receptors. These effects may often be mitigated by reducing the dose of levodopa/carbidopa by approximately 10 to 30%.

    The decision to prescribe selegiline should take into consideration that the MAO system of enzymes is complex and incompletely understood and there is only a limited amount of carefully documented clinical experience with selegiline. Consequently, the full spectrum of possible responses to selegiline may not have been observed in pre-marketing evaluation of the drug. It is advisable, therefore, to observe patients closely for atypical responses.


    Epidemiological studies have shown that patients with Parkinson's disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson's disease or other factors, such as drugs used to treat Parkinson's disease, is unclear. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Eldepryl for any indication. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g., dermatologists).

    Information for patients:

    Patients should be advised of the possible need to reduce levodopa dosage after the initiation of Eldepryl therapy.

    Patients (or their families if the patient is incompetent) should be advised not to exceed the daily recommended dose of 10 mg. The risk of using higher daily doses of selegiline should be explained, and a brief description of the "cheese reaction" provided. Rare hypertensive reactions with selegiline at recommended doses associated with dietary influences have been reported.

    Consequently, it may be useful to inform patients (or their families) about the signs and symptoms associated with MAOI induced hypertensive reactions. In particular, patients should be urged to report, immediately, any severe headache or other atypical or unusual symptoms not previously experienced.

    There have been reports of patients experiencing intense urges to gamble, increased sexual urges, and other intense urges and the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone, that are generally used for the treatment of Parkinson's disease, including Eldepryl. Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Selegiline. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges or other intense urges while taking Eldepryl. Physicians should consider dose reduction or stopping the medication if a patient develops such urges while taking Selegiline HCl pills.

    Drug interactions:

    The occurrence of stupor, muscular rigidity, severe agitation, and elevated temperature has been reported in some patients receiving the combination of selegiline and meperidine. Symptoms usually resolve over days when the combination is discontinued. This is typical of the interaction of meperidine and MAOIs. Other serious reactions (including severe agitation, hallucinations, and death) have been reported in patients receiving this combination. Severe toxicity has also been reported in patients receiving the combination of tricyclic antidepressants, selective serotonin re-uptake inhibitors and selegiline. One case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medication (ephedrine).

    Side effects, adverse reactions:

    The most common side effects of selegiline tablets and capsules in conjunction with levodopa include, in decreasing order of frequency, nausea, hallucinations, confusion, depression, loss of balance, insomnia, increased involuntary movements, agitation, slow or irregular heart rate, delusions, hypertension, new or increased angina pectoris, and syncope.

    Use in specific populations:


    There are no adequate and well-controlled studies in pregnant women. Selegiline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

    Nursing mothers

    It is not known whether selegiline hydrochloride is excreted in human milk. Because many drugs are excreted in human milk, consideration should be given to discontinuing the use of all but absolutely essential drug treatments in nursing women.

    Pediatric use

    The effects of Selegiline HCl in children have not been evaluated.

    Pregnancy categories:

  • B2 - Australia
  • C - United States (Risk cannot be ruled out)

    Salts and other forms:

  • Selegiline Base
  • Selegiline Citrate
  • Selegiline Hydrochloride

    Synonyms, international and chemical names:

  • (-)-Deprenil
  • (R)-(-)-N,alpha-Dimethyl-N-2-propinylphenethylamine
  • (R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)-2-propinylamin
  • Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, (R)-
  • Deprenil
  • Deprenyl
  • L-Deprenalin
  • L-Deprenil
  • L-Deprenyl
  • Selegelin
  • Selegeline
  • Selegiliini
  • Selegilin
  • Selegilina
  • Selegiline HCl
  • Selegilinehydrochloride
  • Selegilinhydrochlorid
  • Selegilini Hydrochloridum
  • Selegilinum
  • Szelegilin

    Brands, generics, trade names:

  • Anipryl - Pfizer, Zoetis
  • Cognitive - Ebewe Pharma, Ever Pharma
  • Deprenyl - Orion Pharma, Sanofi-Aventis
  • Deprilan - Biosintetica Laboratorios
  • Egibren - Chiesi
  • Eldepryl - Orion Corporation
  • Emsam - Mylan
  • Jumex - Sanofi-Aventis, Armstrong Laboratorios de Mexico, Chiesi, Chinoin Pharmaceutical and Chemical Works, Dexxon, DKSH, IDS Group, IVAX, Lexapharm, Metro Drug Distribution, Novartis, Paranova, The Glory Medicina, Torrent Pharmaceuticals, Zuellig Pharma
  • Jumexil - Farmalab Industrias Quimicas e Farmaceuticas
  • Moverdin - Kocak Farma Ilac
  • Niar - Abbott, Knoll
  • Otrasel - Cephalon, Lafon Laboratoires
  • Plurimen - Orion Pharma, Asta Medica, Viatris
  • Selegilin - AbZ-Pharma, Azupharma, CT-Arzneimittel, Mepha, Ratiopharm
  • Selegilina - Davur Laboratorios, Generis Farmaceutica
  • Selegiline - Alphapharm, Apotex, Biogaran, Generics UK, Mylan, Sandoz, Teva
  • Selegos - Medochemie, Britton Distributions, Derek Marketing, Komedic, Star Medical Supplies
  • Selerin - Cipla, Protec
  • Selgian - Ceva Animal Health, Biokema, Ceva Sante Animale, Sanofi-Aventis
  • Selgin - Intas Pharmaceuticals
  • Tonus - Acapi
  • Xilopar - Teva, Cephalon, Elan Pharmaceuticals, Esteve, Segix Italia
  • Zelapar - Teva, B & S Healthcare, Cardinal Health, Cephalon, Elan Pharmaceuticals, Lexon UK, Servipharm, Star Pharmaceuticals, Valeant Pharmaceuticals, Zeneus Pharma

    Here is a list of popular medications containing selegiline as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Sanofi-Aventis
  • Eldepryl
  • Capsules; Oral; Selegiline Hydrochloride 5 mg
  • Syrup; Oral; Selegiline Hydrochloride 10 mg / 5 ml
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Tablets; Oral; Selegiline Hydrochloride 10 mg
  • Orion Corporation
  • Allphar Services
  • Aspen
  • Asta Medica
  • Deprenyl Research
  • Douglas Pharmaceuticals
  • Draxis Health
  • Eisai
  • Ercopharm
  • Eumedica Pharmaceuticals
  • Genepharm
  • Mylan
  • Polyfarma
  • Reckitt Benckiser
  • Servipharm
  • Somerset Pharmaceuticals
  • Star Pharmaceuticals
  • Themis Medicare
  • Viatris
  • Emsam
  • Transdermal Systems; Topical; Selegiline 6 mg / 24 h
  • Transdermal Systems; Topical; Selegiline 9 mg / 24 h
  • Transdermal Systems; Topical; Selegiline 12 mg / 24 h
  • Mylan
  • Bristol-Myers Squibb
  • Somerset Pharmaceuticals
  • Selgin
  • Tablets; Oral; Selegiline Hydrochloride 5 mg
  • Intas Pharmaceuticals

  • References:

  • Selegiline main article on Wikipedia:
  • D-Deprenyl article on Wikipedia:
  • Selegiline compound on PubChem:
  • Selegiline Hydrochloride compound on PubChem:
  • Selegiline medicine on DrugBank:
  • Selegiline Hydrochloride on DrugBank:
  • Selegiline FAQ on MedlinePlus (revised 01/15/2018):
  • Apotex Selegiline Hydrochloride tablets drug label on DailyMed (revised November 28, 2018):
  • Zelapar (Selegiline Hydrochloride) orally disintegrating tablets drug label on DailyMed (revised February 3, 2020):
  • Emsam (Selegiline) patch drug label on DailyMed (revised May 15, 2020):
  • Selegiline containing drugs on
  • Selegiline for sale on Pharma Doctor:
  • Eldepryl (Selegiline Hydrochloride) capsules official prescribing information from the U.S. FDA (issued January 2008):
  • EMSAM (Selegiline Transdermal System) official prescribing information from the U.S. FDA (issued June 2007):
  • Eldepryl (Selegiline Hydrochloride) 5 mg tablets product information from GP2U TeleHealth (revised 28 October 2010):
  • Eldepryl (Selegiline Hydrochloride) 5 mg and 10 mg tablets patient information leaflet from (revised January 2021):

    Revised: June 2021

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